Accompanying diagnosis of precision medicine and personalized treatment

Application Requirements

In precision medicine and personalized therapy, patients have extremely high requirements for the effectiveness and safety of treatment plans, but individual genetic differences and different stages of disease progression often lead to similar symptoms but need differentiated diagnosis and treatment. Traditional detection has low sensitivity and cannot meet the needs of personalized treatment, and the detection cycle is long. Therefore, medical institutions urgently need high-sensitivity and high-specificity detection technology.

Solutions

Point-of-Care Testing (POCT) Solution - iFIND

Sample Processing: Built-in ultrasound combined with chemical lysis + high-efficiency microfiltration membrane purification.
Assay Preparation: Fully enclosed cartridge with pre-filled lyophilized reagents for fully automated assay preparation.
Detection Results: Thin-film reaction zone with average temperature change rate ≥10℃/S; ultra-multiplex detection achieved by multiple probes + probe melting curve analysis.

Open Workstation Solution - Atlas120

Sample Processing: Supports fully automated nucleic acid extraction for up to 12 samples simultaneously.
Assay Preparation: Open detection reagents with robotic arm for automated reaction preparation, full liquid sealing to avoid contamination.
Detection Results: Standard real-time fluorescent quantitative PCR reactions supporting amplification and melting curve analysis; 6-color fluorescence with 4 amplification detection positions per sample, enabling detection of 24 targets.

Rapid Low-Throughput Detection Solution - ArchiPure 16 + Archimed Mini/Mini Pro

Sample Processing: High-purity nucleic acid is extracted from samples (e.g., nasopharyngeal swabs, oropharyngeal swabs) using 16-throughput fully automated nucleic acid extractor, improving the sensitivity and reliability of subsequent detection.
Assay Preparation: Manual preparation of detection system.
Detection Results: Real-time fluorescent quantitative PCR instrument combined with multiplex PCR technology, supporting amplification and melting curve analysis; standard configuration with 4-color fluorescence and 16-throughput, enabling rapid detection of low-throughput samples.

Standard Detection Solution - ArchiPure 32/96 + Archimed X

Sample Processing: High-purity nucleic acid is extracted from samples (e.g., nasopharyngeal swabs, oropharyngeal swabs) using 32/96-throughput fully automated nucleic acid extractor, improving the sensitivity and reliability of subsequent detection.
Assay Preparation: Manual preparation of detection system.
Detection Results: Standard 96-throughput real-time fluorescent quantitative PCR instrument combined with multiplex PCR technology, supporting amplification and melting curve analysis; standard configuration with 4/6-color fluorescence, meeting daily detection needs of standard-throughput experiments.

Application Scenarios

Specialized Cancer Hospitals

Accurately detect mutation status of tumor driver genes, assist in evaluating the efficacy and drug resistance risk of targeted therapy, and provide basis for timely adjustment of treatment plans – POCT, Open Workstation and Standard Detection Solutions are recommended.

Medium and Large General Hospitals

For anti-infective treatment monitoring and drug resistance diagnosis – Open Workstation Solution or Rapid Detection Solution is recommended.

Small Clinics & Community Hospitals

Small number of daily infection patients with basic detection needs only – POCT or Open Workstation Solution is recommended.

Third-Party Testing Centers

For genetic disease testing and pharmacogenomics-guided medication testing – Standard Detection Solution is recommended.

Detection Workflow

Point-of-Care Testing (POCT) Solution - iFIND

Open Workstation Solution - Atlas120

Rapid Detection Solution - ArchiPure 16 + Archimed Mini 16/Mini Pro

Standard Detection Solution - ArchiPure32/96 + Archimed X

Our Advantages

High-Efficiency Detection

All solutions support multiplex detection: POCT solution completes detection within 30 minutes; Open Workstation and Standard Detection solutions save more than 20% of time compared with conventional instruments.

Excellent Sensitivity and Specificity

Combination of automated nucleic acid extraction and high-efficiency real-time fluorescent quantitative PCR ensures high sensitivity and strong specificity, reducing the risk of false positive/false negative results.

Wide Applicability

Multiple solutions support various sample types (e.g., plasma, white blood cells, tissue, etc.) to meet different needs.

Flexible Solution Design

Adaptable to detection reagents according to market demands with strong compatibility.

Success Cases

Scenario: A provincial specialized cancer hospital needed to replace outdated equipment for screening blood samples of non-small cell lung cancer (NSCLC) patients eligible for EGFR-targeted drugs, aiming to optimize treatment plans and improve medication efficiency.

Requirements: The hospital diagnoses over 5,000 lung cancer cases annually with specific testing demands. The Pathology Department mainly conducts EGFR testing on tissue samples, but there is an urgent need for blood ctDNA testing as a supplement for patients who cannot provide tissue samples.

Solution:

With the standard laboratory detection solution provided by Rocgene, the recovery quality and quantity of ctDNA were ensured through targeted blood DNA extraction reagents, and Archimed X6 was adopted for detection to replace the original outdated equipment.

Results:

Upon arrival at the laboratory, ArchiPure32 was used to complete nucleic acid extraction and purification of blood samples. With faster temperature ramping speed and shorter temperature hold time, Archimed X6 reduced the detection time from 90 minutes (original platform) to 75 minutes. Additionally, the light source service life of over 100,000 hours greatly reduced the hospital's usage and subsequent maintenance costs.

On-site Usage Photos

Detection Results